Many thanks to William J. Malone, MD for providing this information for the iatdd website:

  1. Decisions about the discontinuation of any hormone prescribed for any reason should occur under the supervision of a medical professional. 
  2. Suddenly stopping hormones, in particular testosterone, can result in withdrawal symptoms.  Withdrawal symptoms can be physical, including fatigue, loss of appetite, insomnia, muscle and joint pain, and hot flashes, and also psychological, including feelings of depression, mood swings, and suicidal thoughts.
  3. After a hormone is stopped, if withdrawal symptoms occur, the severity of the symptoms usually correlates with the dosage of the hormone taken and the length of time for which it was taken.  Higher dosages taken for longer periods of time, correlate with more severe symptoms. 
  4. If a decision is made to stop a hormone, tapering or slowly lowering the dosage is usually best unless there is a medical reason requiring sudden discontinuation of a hormone.  The length of taper will depend upon the starting dosage of the hormone, the length of time it was taken, and the response to tapering. 
  5. If withdrawal symptoms are severe, a psychological and/or psychiatric evaluation may be needed to help determine the best method to manage those symptoms. 
  6. When a prescribed hormone is stopped, the body will sometimes resume hormone production on its own. In situations where that does not or cannot happen, replacement hormones can be prescribed.  Initiation of replacement hormones should also be supervised by a medical professional. 
  7. If an individual has had surgery such as orchidectomy or oopherectomy changing dosages and types of hormones becomes more complicated, depending upon whether puberty was blocked, and if so, at what stage.  Discontinuation or initiation of any hormone in this setting requires close supervision by an experienced medical professional.    


Brower, K. J. (2009). Anabolic Steroid Abuse and Dependence in Clinical Practice. The Physician and Sportsmedicine, 37(4), 131-140. doi:10.3810/psm.2009.12.1751

Kanayama, G., & Pope, H. G. (2013). Anabolic-Androgenic Steroid Use and Dependence. Principles of Addiction, 743-753. doi:10.1016/b978-0-12-398336-7.00075-9

Margolin, L., Cope, D. K., Bakst-Sisser, R., & Greenspan, J. (2007). The Steroid Withdrawal Syndrome: A Review of the Implications, Etiology, and Treatments. Journal of Pain and Symptom Management, 33(2), 224-228. doi:10.1016/j.jpainsymman.2006.08.013

Testosterone Withdrawal Symptoms: What You May Notice. (2015, November 27). Retrieved from